Manufacturing/Use Information:  TRICHLOROETHYLENE (79-01-6)

Major Uses:

For Trichloroethylene (USEPA/OPP Pesticide Code: 081202) there are 0 labels match. /SRP: Not registered for current use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./
[U.S. Environmental Protection Agency/Office of Pesticide Program's Chemical Ingredients Database on Trichloroethylene (79-01-6). Available from the Database Query page at http://www.cdpr.ca.gov/docs/epa/epamenu.htm as of october 24, 2002.]**QC REVIEWED**

Therap cat: anesthetic (inhalation)/former use/; Therap cat (vet): anesthetic (inhalation)
[Budavari, S. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 1996., p. 1643]**PEER REVIEWED**

IN GAS PURIFICATION, AS A SOLVENT OF SULFUR & PHOSPHORUS
[Browning, E. Toxicity and Metabolism of Industrial Solvents. New York: American Elsevier, 1965., p. 190]**PEER REVIEWED**

Aerospace operations (flushing liquid oxygen)
[Lewis, R.J., Sr (Ed.). Hawley's Condensed Chemical Dictionary. 13th ed. New York, NY: John Wiley & Sons, Inc. 1997., p. 1125]**PEER REVIEWED**

AGENT IN REMOVAL OF BASTING THREADS IN TEXTILE PROCESSING
[SRI, p. ]**PEER REVIEWED**

CHEM INT FOR 1,1,2,2-TETRACHLOROETHYL SULFENYL CHLORIDE
[SRI, p. ]**PEER REVIEWED**

SOLVENT BASE FOR METAL PHOSPHATIZING SYSTEMS
[SRI, p. ]**PEER REVIEWED**

SOLVENT IN CHARACTERIZATION TEST FOR ASPHALT
[SRI, p. ]**PEER REVIEWED**

ENTRAINER FOR RECOVERY OF FORMIC ACID
[SRI, p. ]**PEER REVIEWED**

Used as household cleaner; with trichloroethane it is used in most typewriter correction fluid. /SRP: Former use/
[Arena, J.M. and Drew, R.H. (eds.) Poisoning-Toxicology, Symptoms, Treatments. 5th ed. Springfield, IL: Charles C. Thomas Publisher, 1986., p. 257]**PEER REVIEWED**

Used in wool-fabric scouring
[CONSIDINE. CHEMICAL AND PROCESS TECHNOL ENCYC 1974 p.1109]**PEER REVIEWED**

Intermediate in the production of pentachloroethane.
[WHO; Environ Health Criteria 50: Trichloroethylene p.30 (1985)]**PEER REVIEWED**

Carrier solvent for the active ingredients of insecticides, and fungicides.
[WHO; Environ Health Criteria 50: Trichloroethylene p.30 (1985)]**PEER REVIEWED**

MEDICATION
**PEER REVIEWED**

MEDICATION (VET)
**PEER REVIEWED**

Used in the preparation of insecticidal fumigants.
[Hayes, W.J., Jr., E.R. Laws, Jr., (eds.). Handbook of Pesticide Toxicology. Volume 2. Classes of Pesticides. New York, NY: Academic Press, Inc., 1991., p. 690]**PEER REVIEWED**

Trichloroethylene
was used earlier as an extraction solvent for natural fats and oils, such as palm, coconut and soya bean oils. It was also an extraction solvent for spices, hops and the decaffeination of coffee. The United States Food and Drug Administration banned these uses of trichloroethylene...its use in cosmetic and drug products was also discontinued...It was used as both an anesthetic and an analgesic in obstetrics. /Former uses/
[IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work)., p. V63 (95) 80]**PEER REVIEWED**

Trichloroethylene has been used, in limited quantities, to control relative molecular mass in the manufacture of polyvinyl chloride. It has also been used as a solvent in the rubber industry, some adhesive formulations and in research laboratories. In the textile industry, it is used as a carrier solvent for spotting fluids and as a solvent in dyeing and finishing. It is also used as a solvent in printing inks, paint, lacquers, varnishes, adhesives and paint strippers.
[IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work)., p. V63 (95) 80]**PEER REVIEWED**

The major use of trichloroethylene is in metal cleaning or degreasing. Trichloroethylene is used in degreasing operations in five main industrial groups: furniture and fixtures, fabricated metal products, electric and electronic equipment, transport equipment and miscellaneous manufacturing industries. It is also used in plastics, appliances, jewellery, automobile, plumbing fixtures, textiles, paper, glass and printing industries.
[IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work)., p. V63 (95) 80]**PEER REVIEWED**

Used as a chemical intermediate in the synthesis of captafol; chloroacetic acid; 1-chloro-2,2,2-trifluoroethane
[Ashford, R.D. Ashford's Dictionary of Industrial Chemicals. London, England: Wavelength Publications Ltd., 1994., p. 905]**PEER REVIEWED**

Stabilized grades are produced for vapor cleaning applications
[Ashford, R.D. Ashford's Dictionary of Industrial Chemicals. London, England: Wavelength Publications Ltd., 1994., p. 905]**PEER REVIEWED**

Use of trichloroethylene in fluorocarbon production and as a metal cleaning and degreasing solvent are both increasing. In vapor degreasing, trichloroethylene has regained some market share as a result of the phaseout of 1,1,1-trichloroethane for emissive uses. Growth prospects for trichloroethylene as a fluorocarbon feedstock hold more potential, however, particularly its use as a precursor for the workhorse hydrofluorocarbon product, HFC-134a.
[Chemical Marketing Reporter; Chemical Profile Trichloroethylene. Dec 8, 1997. NY, NY: Schnell Pub Co (1997)]**PEER REVIEWED**

Manufacturers:

Dow Chemical USA, Hq, 2030 Dow Center, Midland, MI 48674, (517) 636-1000; Production site: Freeport, TX 77541
[SRI International. 2000 Directory of Chemical Producers -- United States. SRI Consulting, Menlo Park: CA 2000, p. 946]**PEER REVIEWED**

PPG Industries, Inc., Hq, One PPG Place, 36 East, Pittsburgh, PA 15272, (412) 434-3131; Chemicals Group; Production site: Lake Charles, LA 70602
[SRI International. 2000 Directory of Chemical Producers -- United States. SRI Consulting, Menlo Park: CA 2000, p. 946]**PEER REVIEWED**

Methods of Manufacturing:

Until 1968, about 85% of United States production capacity of trichloroethylene was based on acetylene. The acetylene-based process consists of two steps: acetylene is first chlorinated to 1,1,2,2-tetrachloroethane, with a ferric chloride, phosphorus chloride or antimony chloride catalyst, and the product is then dehydrohalogenated to trichloroethylene. The current method of manufacture is from ethylene or 1,2-dichloroethane. In a process used by one plant in the United States, trichloroethylene is produced by noncatalytic chlorination of ethylene dichloride and other C2 hydrocarbons with a mixture of oxygen and chlorine or hydrogen chloride.
[IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work)., p. V63 (95) 79]**PEER REVIEWED**

Ethylene dichloride + chlorine (chlorination; coproduced with perchloroethylene)
[Ashford, R.D. Ashford's Dictionary of Industrial Chemicals. London, England: Wavelength Publications Ltd., 1994., p. 905]**PEER REVIEWED**

Ethylene dichloride + chlorine + oxygen (oxychlorination/dehydrochlorination; coproduced with perchloroethylene)
[Ashford, R.D. Ashford's Dictionary of Industrial Chemicals. London, England: Wavelength Publications Ltd., 1994., p. 905]**PEER REVIEWED**

General Manufacturing Information:

Since there are now only two producers (Dow & PPG), the USITC stopped publicly reporting production and other statistics at the end of 1982
[CHEMICAL PRODUCTS SYNOPSIS: Trichloroethylene, 1985]**PEER REVIEWED**

Depending on the condition, dissociation of HCl at elevated temperatures in the presence of carbon in a chemical plasma will produce 1,1,2-trichloroethane, 1,2-dichloroethane, trichloroethylene, and perchloroethylene.
[Kirk-Othmer Encyclopedia of Chemical Technology. 3rd ed., Volumes 1-26. New York, NY: John Wiley and Sons, 1978-1984., p. V12 1008 (1980)]**PEER REVIEWED**

Cancelled for use in fumigant mixture or as a solvent with other ingredient on grains.
[Farm Chemicals Handbook 2000. Willoughby, OH: Meister Publishing Co. p. C 394 (2000)]**PEER REVIEWED**

Formulations/Preparations:

Trichloroethylene for medicinal purposes may contain thymol as a preservative. Industrial grades ... may contain stabilizers, such as triethanolamine.
[Budavari, S. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 1996., p. 1643]**PEER REVIEWED**

Grades: USP; technical; high purity; electronic; metal degreasing; extraction.
[Lewis, R.J., Sr (Ed.). Hawley's Condensed Chemical Dictionary. 13th ed. New York, NY: John Wiley & Sons, Inc. 1997., p. 1125]**PEER REVIEWED**

Trichloroethylene is available in the USA in high-purity, electronic USP, technical, metal degreasing and extraction grades
[IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work)., p. V20 545 (1979)]**PEER REVIEWED**

Commercial grades of trichloroethylene, formulated to meet use requirements, differ in the amount and type of added inhibitor. Typical grades contain >99% trichloroethylene; they include a neutrally inhibited vapor-degreasing grade and a technical grade for use in formulations.
[IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work)., p. V63 (95) 76]**PEER REVIEWED**

Stabilizers that have been used in formulations of trichloroethylene include neutral inhibitors and free-radical scavengers, amyl alcohol, n-propanol, isobutanol, 2-pentanol, diethylamine, triethylamine, dipropylamine, diisopropylamine, diethanolamine, triethanolamine, morpholine, N-methylmorpholine, aniline, acetone, ethyl acetate, borate esters, ethylene oxide, propylene oxide, 1,2-epoxybutane, cyclohexene oxide, butadiene dioxide, styrene oxide, pentene oxide, 2,3-epoxy-1-propenol, 3-methoxy-1,2-epoxypropane, stearates, 2,2,4-trimethyl-1-pentene, 2-methyl-1,2-epoxypropanol, epoxycyclopentanol, epichlorohydrin, tetrahydrofuran, tetrahydropyran, 1,4-dioxane, dioxalane, trioxane, alkoxyaldehyde hydrazones, methyl ethyl ketone, nitromethanes, nitropropanes, phenol, ortho-cresol, thymol, para-tert-butylphenol, para-tert-amylphenol, isoeugenol, pyrrole, N-methylpyrrole, N-ethylpyrrole, (2-pyrryl)trimethylsilane, glycidyl acetate, isocyanates and thiazoles.
[IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work)., p. V63 (95) 76]**PEER REVIEWED**

Impurities:

Acidity (as hydrochloric acid), 0.0005% max; alkalinity (as sodium hydroxide), 0.001% max; residue on evaporation, 0.005% max; antioxidants, such as amine (0.001-0.01% or more) or combinations of epoxides such as epichlorohydrin & esters (0.2-2% total)
[IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work)., p. V20 547 (1979)]**PEER REVIEWED**

Apart from added stabilizers, commercial grades of trichloroethylene should not contain more than the following amounts of impurities: water, 100 ppm; acidity (as HCl), 5 ppm; insoluble residue, 10 ppm. Free chlorine should not be detectable.
[IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work)., p. V63 (95) 76]**PEER REVIEWED**

Impurities that have been found in commercial trichloroethylene products include: carbon tetrachloride, chloroform, 1,2-dichloroethane, trans-1,2-dichloroethylene, cis-1,2-dichloroethylene, pentachloroethane, 1,1,1,2-tetrachloroethane, 1,1,2,2-tetrachloroethane, 1,1,1-trichloroethane, 1,1,2-trichloroethane, 1,1-dichloroethylene, tetrachloroethylene, bromodichloromethane, bromodichloroethylene, and benzene.
[IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work)., p. V63 (95) 76]**PEER REVIEWED**

Consumption Patterns:

Demand: (1982): 240 million pounds; (1983): Est 235 million pounds; 1987: Est 215 million pounds.
[Kavaler. Chem Market Reporter (1983)]**PEER REVIEWED**

Vapor degreasing of fabricated metal parts, 80%; chemical intermediate, 5%; miscellaneous used, 5%; exports, 10% (1985)
[CHEMICAL PROFILE: Trichloroethylene, 1986]**PEER REVIEWED**

Vapor degreasing of fabricated metal parts, 66%; chemical intermediates, miscellaneous domestic uses, 5%; exports, 22%.
[Kavaler. Chem Market Reporter (1983)]**PEER REVIEWED**

Vapor degreasing of fabricated metal parts, 65%; chemical intermediates and miscellaneous uses, 35%.
[Chemical Marketing Reporter; Chemical Profile Trichloroethylene. Dec 8, 1997. NY, NY: Schnell Pub Co (1997)]**PEER REVIEWED**

Demand: 1996: 180 million pounds; 1997: 190 million pounds; 2001: 230 million pounds (includes exports)
[Chemical Marketing Reporter; Chemical Profile Trichloroethylene. Dec 8, 1997. NY, NY: Schnell Pub Co (1997)]**PEER REVIEWED**

U. S. Production:

USA production: (1981): 258,182 pounds.
[United States International Trade Commission. Synthetic Organic Chemicals-- United States Production and Sales, 1981. USITC Publications 1291 Washington, DC: United States International Trade Commission, 1981., p. 1132]**PEER REVIEWED**

Production quantities (1976): 610X10+6 pounds.
[Fishbein L; Potential Indust Carcins and Mutagens p.35 (1977) USEPA 560/ 5-77-005]**PEER REVIEWED**

(1985) 7.72X10+10 g /Estimated/
[CHEMICAL PRODUCTS SYNOPSIS: Trichloroethylene, 1985]**PEER REVIEWED**

(1991) 320 million lb
[SRI. 1992 Directory of Chemical Producers-United States of America. Menlo Park, CA: SRI International, 1992., p. 1032]**PEER REVIEWED**

U. S. Imports:

(1985) 1.98X10+10 g
[BUREAU OF THE CENSUS. U.S. IMPORTS FOR CONSUMPTION AND GENERAL IMPORTS 1985 p.1-584]**PEER REVIEWED**

Imports last year totaled approximately 10 million pounds, averaging 12 million pounds during the period.
[Chemical Marketing Reporter; Chemical Profile Trichloroethylene. Dec 8, 1997. NY, NY: Schnell Pub Co (1997)]**PEER REVIEWED**

U. S. Exports:

(1985) 1.06X10+10 g
[BUREAU OF THE CENSUS. U.S. EXPORTS, SCHEDULE E, 1985 p.2-69]**PEER REVIEWED**

Exports were 65 million pounds during 1996, but averaged 83 million pounds per year in the 1992-1996 period.
[Chemical Marketing Reporter; Chemical Profile Trichloroethylene. Dec 8, 1997. NY, NY: Schnell Pub Co (1997)]**PEER REVIEWED**

SOURCE: http://toxnet.nlm.nih.gov/cgi-bin/sis/search/f?./temp/~Mzqj4W:1