Information Regarding Acetone and Adhesive

http://toxnet.nlm.nih.gov/cgi-bin/sis/search/f?./temp/~YevjIo:1
ACETONE
CASRN: 67-64-1

Major Uses :

CHEM INT FOR METHYL METHACRYLATE, METHACRYLIC ACID & HIGHER METHACRYLATES, METHYL ISOBUTYL KETONE, METHYL ISOBUTYL CARBINOL, BISPHENOL A, ISOPHORONE; SPINNING SOLVENT IN MFR OF CELLULOSE ACETATE; SOLVENT FOR ADHESIVES & PRINTING INKS, ACETYLENE
[SRI]**PEER REVIEWED**

Environmental Fate/Exposure Summary :

Acetone's production and use as a solvent for fats, oils, waxes, resins, rubbers, plastics, pharmaceuticals and rubber cements may result in its release to the environment through various waste streams. Its use as an extracting reagent and starting material or intermediate in the manufacture of chemical products will also lead to its release to the environment. Acetone occurs naturally as a metabolic byproduct of plants and animals and is released into the atmosphere by volcanoes and forest fires. Based on an experimental vapor pressure of 231 mm Hg at 25 deg C, acetone is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase acetone is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals with an estimated atmospheric half-life of 71 days. Acetone also undergoes photodecomposition by sunlight with an estimated half-life of about 80 days. Acetone is expected to have very high mobility in soils based upon an estimated Koc value of 1. Volatilization from dry soil surfaces is expected based upon the vapor pressure of this compound. Volatilization from moist soil surfaces is also expected based upon the measured Henry's Law constant of 1.87X10-5 atm-cu m/mol. This compound is expected to biodegrade under aerobic and anaerobic conditions. In water, acetone is not expected to adsorb to suspended solids or sediment based upon its estimated Koc value. Volatilization from water surfaces is expected to be an important environmental fate process given its estimated Henry's Law constant. Estimated half-lives for a model river and model lake are 38 and 333 hours, respectively. Experimentally determined volatilization half-lives in a shallow stream were measured in the range of 8-18 hours. Bioconcentration in aquatic organisms is considered low based upon an estimated BCF value of 1. Occupational exposure may be through inhalation and dermal contact with this compound at workplaces where acetone is produced or used. The general population may be exposed to acetone through the use of commercially available products containing this compound such as paints, adhesives, cosmetics, and rubber cements. Exposure will also arise from inhalation of ambient air, ingestion of drinking water, and food that contains acetone. (SRC)
**PEER REVIEWED**

Probable Routes of Human Exposure :

The general population may be exposed to acetone through the use of commercially available products containing this compound such as paints, adhesives, cosmetics, and rubber cements(SRC). Exposure will also arise from inhalation of ambient air, ingestion of drinking water, and food that contains acetone(SRC). The average blood concn of acetone in 600 non-occupationally exposed persons in the US was 3,100 ppb(1).
[(1) Ashley DL et al; Clin Chem 40: 1401-04 (1994)]**PEER REVIEWED**

GLCC RELATED TOXIC SUBSTANCES FOUND IN THE CAMP POND AND CAMP WATER WELL 2003 AND 2004

GREAT LAKES CHEMICAL CORPORATION AND THE PATHFINDERS CAMP