GREAT LAKES CHEMICAL CORPORATION AND CHEMICALS RELATED TO DIABETES

http://toxnet.nlm.nih.gov/cgi-bin/sis/search/f?./temp/~5JBgJd:5
1-BROMO-3-CHLOROPROPANE
CASRN: 109-70-6

Atmospheric Concentrations :

URBAN/SUBURBAN: Source-dominated air samples contained 1-bromo-3-chloropropane at a median concentration of 2 parts/trillion(1). Air samples collected from a geographic area associated with the bromine industry in Arkansas contained 1-bromo-3-chloropropane at unreported concentrations(2). Ambient concentrations of 1-bromo-3-chloropropane in air surrounding the Ethyl Corporation, Magnolia, AK in July 1977 ranged from trace levels to 1,688 ng/cu m(3). Ambient concentrations of 1-bromo-3-chloropropane in air surrounding the Great Lakes Corporation and the Michigan Chemical Corporation in El Dorado, AK in July 1977 ranged from not detected to trace levels and trace to 63 ng/cu m, respectively(3).
[(1) Brodzinsky R, Singh HB; Volatile Organic Chemicals in the Atmosphere: An assessment of Available Data. Menlo Park, CA: Atmospheric Science Center. SRI International. Contract 68-02-3452 (1982) (2) DeCarlo VJ; Ann NY Acad Sci 320: 678-81 (1979) (3) Pellizzari ED et al; Environmental Monitoring Near Industrial Sites: Brominated Chemicals Part I. Washington, DC: USEPA. Office of Toxic Substances (1978)]**PEER REVIEWED**

A historical prospective mortality study was conducted for 3579 white male workers employed between 1935 and 1976 at four Vesicol Chemical Corporation facilities. The members of the study cohort were potentially exposed to brominated compounds including 1,2-dibromo-3-chloropropane (DBCP), tris(2,3-dibromopropyl)phosphate, trimethylene chlorobromide. Some were exposed to DDT, polybrominated biphenyls (PBB) and others to radiation from rare earths process. Overall mortality was lower than expected, particularly in diseases of the circulatory system, nonmalignant respiratory diseases and diseases of the digestive system. No significant overall or cause specific mortality excess was noted among those potentially exposed to either TRIS or DDT. No cancer death was noted among the rare earth employees. Mortality from diabetes mellitus was significantly elevated among the maintenance workers hired in the early 1940's. A significant mortality excess due to diseases of the circulatory system was observed among workers potentially exposed to DBCP and or rare earth process. Mortality from testicular cancer was significantly higher in those exposed to organic bromides. The common potential exposure of the testicular cancer decedents was methyl bromide. A number of other cause specific mortality excesses were also noted.
[Anon; An Historical Prospective Mortality Study of Vesicol Workers Potentially Exposed to Brominated Chemicals. Tabershaw Occupational Med Associates, Rockville, MD 121 pp. (1981)]**PEER REVIEWED**

GREAT LAKES CHEMICAL CORPORATION AND THE PATHFINDERS CAMP