DL-ALPHA-TOCOPHEROL

http://toxnet.nlm.nih.gov/cgi-bin/sis/search
DL-ALPHA-TOCOPHEROL
CASRN: 10191-41-0

Substance Identification:

Substance Name: DL-ALPHA-TOCOPHEROL
CAS Registry Number: 10191-41-0

Data Type:

Tumor Promotion
Tumor Inhibition

Studies Data:

Tumor Promotion Studies:

 

Species:	MOUSE
Strain/Sex:	SENCAR/FEMALE
Route (Promoter):	DERMAL
Dose (Promoter):	0; 80 UMOL IN 0.2 ML ACETONE 2/WK BEGINNING 1 WK POST CARCINOGEN DOSE AND CONTINUING FOR 19 WK (STUDY DURATION: 20 WK)
Carcinogen:	7,12-DIMETHYLBENZ[A]ANTHRACENE ; 57-97-6
Route (Carcinogen):	DERMAL
Dose (Carcinogen):	10 NMOL IN 0.2 ML ACETONE ONCE
Target Tissue: Type of Lesion:	SKIN: PAPILLOMA
Reference:

[MITCHEL,REJ AND MCCANN,R; VITAMIN E IS A COMPLETE TUMOR PROMOTER IN MOUSE SKIN; CARCINOGENESIS 14(4):659-662, 1993]

Tumor Inhibition Studies:

 

Species:	HAMSTER
Number of Animals Tested:	(20/20)/(20/20)
Strain/Sex:	SYRIAN/MALE, FEMALE
Dose (Inhibitor):	10 MG IN PEANUT OIL 2/WK FOR 16 WK ON ALTERNATE DAYS WITH CARCINOGEN TREATMENT (STUDY DURATION: 16 WK)
Route (Inhibitor):	TOPICAL
Carcinogen:	7,12-DIMETHYLBENZ[A]ANTHRACENE ; 57-97-6
Route (Carcinogen):	DERMAL
Dose (Carcinogen):	0.5% IN HEAVY MINERAL OIL 3/WK FOR 16 WK
Promoter:	NONE USED
Target Tissue: Type of Lesion:	ORAL CAVITY (CHECK POUCH): TUMOR
Endpoint (Latency):	10 WK, 12 WK, NOT CALCULATED
Comments:	4 ANIMALS/GROUP (2 M, 2 F) WERE KILLED AFTER 8, 10, 12, 14 AND 16 WK OF TREATMENT. MULTIPLICITY RESULTS ARE TOTAL NUMBER OF TUMORS OBSERVED DURING AUTOPSY 32, 19, 40%, P<0.01.
Reference:

[SHKLAR,G; ORAL MUCOSAL CARCINOGENESIS IN HAMSTERS: INHIBITION BY VITAMIN E; J. NATL. CANCER INST. 68(5):791-797, 1982]

 

Species:	MOUSE
Number of Animals Tested:	(17,17)/(16,16)
Strain/Sex:	C57BL/FEMALE
Dose (Inhibitor):	30; 172 MG/KG IN DIET BEGINNING POST CARCINOGEN TREATMENT AND CONTINUING FOR 22 WK (STUDY DURATION: 25 WK)
Route (Inhibitor):	ORAL
Carcinogen:	N-NITROSOMETHYLBENZYLAMINE ; 937-40-6
Route (Carcinogen):	GAVAGE
Dose (Carcinogen):	0.2 MG/KG IN CORN OIL 3/WK FOR 3 WK
Promoter:	ETHANOL ; 64-17-5
Route (Promoter):	ORAL
Dose (Promoter):	SUBSTITUTED FOR MALTOSE DEXTRIN IN DIET TO PROVIDE 30% OF TOTAL DIETARY CALORIES BEGINNING POST CARCINOGEN TREATMENT AND CONTINUING FOR 22 WK
Target Tissue: Type of Lesion:	ESOPHAGUS: TUMOR
Endpoint (Incidence):	10/17 (59%), 6/16 (38%), 36%, NOT CALCULATED
Endpoint (Multiplicity):	8.41, 2.93, 65%, NOT CALCULATED
Comments:	CONTROL DIET CONTAINED 30 MG/KG AGENT.
Reference:

[ESKELSON,CD, ODELEYE,OE, WATSON,RR, EARNEST,DL AND MUFTI,SI; MODULATION OF CANCER GROWTH BY VITAMIN E AND ALCOHOL; ALCOHOL ALCOHOL. 28(1):117-125, 1993]

 

Species:	MOUSE
Number of Animals Tested:	(15,15)/(15,15)
Strain/Sex:	C57BL/FEMALE
Dose (Inhibitor):	30; 172 MG/KG IN DIET BEGINNING POST CARCINOGEN TREATMENT AND CONTINUING FOR 22 WK (STUDY DURATION: 25 WK)
Route (Inhibitor):	ORAL
Carcinogen:	N-NITROSOMETHYLBENZYLAMINE ; 937-40-6
Route (Carcinogen):	GAVAGE
Dose (Carcinogen):	0.2 MG/KG IN CORN OIL 3/WK FOR 3 WK
Promoter:	NONE USED
Target Tissue: Type of Lesion:	ESOPHAGUS: TUMOR
Endpoint (Incidence):	6/15 (40%), 3/15 (20%), 50%, NOT CALCULATED
Endpoint (Multiplicity):	3.26, 1.06, 67%, NOT CALCULATED
Comments:	CONTROL DIET CONTAINED 30 MG/KG AGENT.
Reference:

[ESKELSON,CD, ODELEYE,OE, WATSON,RR, EARNEST,DL AND MUFTI,SI; MODULATION OF CANCER GROWTH BY VITAMIN E AND ALCOHOL; ALCOHOL ALCOHOL. 28(1):117-125, 1993]

 

Species:	MOUSE
Number of Animals Tested:	(35,?)/(35,?)
Strain/Sex:	C3H/HEN/FEMALE
Dose (Inhibitor):	0; 25 MG IN 200 UL ACETONE 3/WK FOR DURATION OF STUDY BEGINNING 3 WK PRIOR TO IRRADIATION (STUDY DURATION: 33 WK)
Route (Inhibitor):	DERMAL
Carcinogen:	UVB IRRADIATION
Route (Carcinogen):	DERMAL
Dose (Carcinogen):	6 J/M2/SEC 30 MIN/D, 5 D/WK FOR 27 WK
Promoter:	NONE USED
Target Tissue: Type of Lesion:	SKIN: TUMOR
Endpoint (Incidence):	81%, 42%, 48%, P=0.0065
Comments:	IN AN AGENT-TREATED GROUP ALSO FED 1% BETA-CAROTENE, TUMOR INCIDENCE WAS REDUCED TO 24%.
Reference:

[GENSLER,HL AND MAGDALENO,M; TOPICAL VITAMIN E INHIBITION OF IMMUNOSUPPRESSION AND TUMORIGENESIS INDUCED BY ULTRAVIOLET IRRADIATION; NUTR. CANCER 15(2):97-106, 1991]

Administrative Information:

CCRIS Record Number: 5853

Last Revision Date: 19960304

Update History:

Complete Update on 03/04/1996, 3 fields added/edited/deleted.
Complete Update on 07/03/1995, 3 fields added/edited/deleted.
Complete Update on 04/07/1995, 4 fields added/edited/deleted.
Complete Update on 10/06/1994, 7 fields added/edited/deleted.

http://toxnet.nlm.nih.gov/cgi-bin/sis/search
DL-ALPHA-TOCOPHEROL
CASRN: 10191-41-0

Substance Identification:

Substance Name: DL-ALPHA-TOCOPHEROL
CAS Registry Number: 10191-41-0

Chemical Classification Category:  Alcohols and phenols

Taxonomic Name & Assay:  In vitro mammalian, SCE - other genotoxic effects

Mutagenicity Studies:

GENE-TOX Evaluation B (post-1980):

 

Species/Cell Type:	Human
Assay Type:	Sister-chromatid exchange (SCE) in vitro
Assay Code:	SC1T
Results:	No conclusion
Panel Report:	EMIC/91392; Mutat Res 297:101-180,1993
Reference:	EMICBACK/60024; MUTAT RES 156:117-121,1985

Species/Cell Type:	Human lymphocytes
Assay Type:	Sister-chromatid exchange (SCE) in vitro
Assay Code:	SCLT
Results:	No conclusion
Panel Report:	EMIC/91392; Mutat Res 297:101-180,1993
Reference:	EMICBACK/60024; MUTAT RES 156:117-121,1985

Administrative Information:

GENETOX Record Number:

2972

Last Revision Date:

19950817

Update History:

Field Update on 08/17/1995, 1 field added/edited/deleted.
Field Update on 08/17/1995, 1 field added/edited/deleted.
Complete update on 01/30/1991, 4 fields added/edited/deleted.

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